The role of rapid capillary resistance decreases in the BOLD response assessed through simulations in a realistic vascular network

13/08/2020: 14:20  - 15:05 
1101 
Combined Educational & Scientific Session 
Room: Thursday Parallel 4 


The
brain’s physiology may fundamentally limit the achievable spatial
and temporal specificity of gradient-echo fMRI. Even if the
physiology does not pose such a limitation a better understanding
would allow for data analysis techniques that improve the spatial
specificity. Microscopy allows for highly detailed investigations of
local physiological mechanism and provides a growing knowledge from
which fMRI may benefit profoundly. A current challenge is the
transition from focal mechanisms to their consequence on the
mesoscopic scale of BOLD examinations. In this abstract we present
our recent work on this transition using simulations of the BOLD
effect.


 

Author String

Joerg Pfannmoeller, Louis Gagnon, Avery Berman, Jonathan Polimeni 

Institution String

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Physics, Engineering Physics and Optics, Laval University, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital 

Speaker

Joerg Pfannmoeller, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital