Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI

13/08/2020: 15:50  - 16:35 
1354 
Oral 
Room: Thursday Parallel 4 
We applied line-scanning fMRI to investigate evoked hemodynamic responses in both laminar-specific gray matter (GM) and white matter (WM) in rats. Based on the WM-specific cross-correlation lag time to the laminar-specific fMRI signal, distinct WM hemodynamic responses were characterized across animals, showing a biphasic HRF with earlier lag times and a monophasic HRF with later lag times. Also, the lag-time dependent HRFs were detected in the subcortical area under the WM. Elucidating neurovascular coupling characteristics of distinct WM hemodynamic responses may help understand the progression of WM-related diseases, e.g. multiple sclerosis (MS) or small vessel disease (SVD).

Author String

Sangcheon Choi, Hang Zeng, Bharat Biswal, Bruce Rosen, Xin Yu 

Institution String

Max Planck Institute for Biological Cybernetics, Graduate Training Centre of Neuroscience, Max Planck Institute for Biological Cybernetics, Graduate Training Centre of Neuroscience, Department of Biomedical Engineering, NJIT, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Max Planck Institute for Biological Cybernetics, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital 

Speaker

Sangcheon Choi, Max Planck Institute for Biological Cybernetics