Mapping directional functional connectivity across brain-wide networks with layer-specific CBV-fMRI

13/08/2020: 15:05  - 15:50 
Room: Thursday Parallel 4 
With recent advances in ultra-high-field MRI hardware and sequence mechanisms, it has become possible to measure CBV-weighted fMRI signal across cortical layers. While initial proof-of-principle layer-fMRI studies in primary brain areas with conventional fMRI task designs are promising, layer-fMRI has not yet realized its full potential to map layer-dependent functional connectivity across large-scale brain networks. In this study, we investigate the applicability of CBV-weighted layer-fMRI to assess functional connectivity during resting-state and naturalistic tasks. We can map common resting-state networks and characterize their internal layer-dependent signatures with respect to directionality and cortical hierarchy.

Author String

Laurentius Huber, Emily Finn, Sean Marrett, Sriranga Kashyap, Arman Khojandi, Rainer Goebel, Peter Bandettini, Benedikt Poser 

Institution String

Faculty of Psychology and Neuroscience, NIMH, NIMH, Faculty of Psychology and Neuroscience, NIMH, Faculty of Psychology and Neuroscience, NIMH, Faculty of Psychology and Neuroscience 


Renzo Huber, MBIC, Uni Maastricht