Cortical-depth dependence of pure T2-weighted BOLD fMRI with minimal T2’ contamination using Echo-Planar Time-resolved Imaging (EPTI)

13/08/2020: 15:05  - 15:50 
1229 
Oral 
Room: Thursday Parallel 4 
BOLD fMRI based on T2 contrast has the promise to provide
exclusively microvascular specificity, which would optimize the ability of fMRI
signals to accurately reflect and localize neuronal activity. However, it is
challenging in practice to achieve pure T2 weighting. Here we employ a new
highly-efficient acquisition and reconstruction framework based on EPI,
Echo-Planar Time-resolved Imaging (EPTI), and extend it to generate blurring- and distortion-free data with purely T2 weighting. We evaluate the technique
through a cortical-depth analysis of activation in human visual cortex and
demonstrate that it achieves the desired microvascular specificity.

Author String

Fuyixue Wang, Zijing Dong, Qiyuan Tian, Jingyuan Chen, Anna Izabella Blazejewska, Timothy Reese, Jonathan Polimeni, Kawin Setsompop 

Institution String

A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard-MIT Health Sciences and Technology, MIT, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 3Department of Electrical Engineering and Computer Science, MIT, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard-MIT Health Sciences and Technology, MIT, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard-MIT Health Sciences and Technology, MIT 

Speaker

Fuyixue Wang, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital