White matter resting-state BOLD signals depend on the orientation of the local diffusion tensor axis relative to the B0-field

13/08/2020: 15:50  - 16:35 
1367 
Oral 
Room: Thursday Parallel 4 
We aimed to test whether the amplitudes of resting-state BOLD signals within the white matter depend on the orientation of the local diffusion tensor relative to the B0-field. This was assessed using resting-state BOLD and diffusion data provided by the HCP. Baseline BOLD signals were about 11% higher in voxels where primary DTI directions were parallel to B0 compared to perpendicular. Because myelinated fibres will change local tissue T2*, which will also impact the BOLD signal, we tested whether the observed BOLD orientation effect was driven by static effects on the baseline or dynamic effects from changes in blood oxygenation.

Author String

Olivia Viessmann, Qiyuan Tian, MichaĆ«l Bernier, David Salat, Jonathan Polimeni 

Institution String

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, VA Boston Healthcare System, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Massachusetts Institute of Technology 

Speaker

Olivia Viessmann, Martinos Center, Massachusetts General Hospital, Harvard Medical School