Ultrahigh-resolution Laminar fMRI Mapping of Cat Visual Cortex at 9.4T: Comparison of 2D GE-EPI and 3D iv-GRASE Sequences

13/08/2020: 15:05  - 15:50 
1220 
Oral 
Room: Thursday Parallel 4 
Blood oxygenation-level dependent (BOLD) fMRI studies at the
level mesoscopic organizations, such as cortical columns and layers, is challenged
by the low signal-to-noise ratio (SNR) and the specificity of different fMRI sequences
even at ultrahigh magnetic fields. In this work, we show that when mapping layer-specific
activities in the cat visual cortex, ultrahigh-resolution 3D GRASE sequence with inner volume selection achieved similar specificity
as at 9.4 Tesla CBV-fMRI using 2D GE-EPI sequence, while attains a higher BOLD
sensitivity. Our results indicate that 3D iv-GRASE BOLD is
promising for laminar and columnar mapping of brain functions.

Author String

Wei Zhu, Djaudat Idiyatullin, Shinho Cho, Yi Zhang, Kâmil Uğurbil, Xiao-Hong Zhu, Wei Chen 

Institution String

University of Minnesota, University of Minnesota, University of Minnesota, University of Minnesota, University of Minnesota, University of Minnesota, University of Minnesota 

Speaker

Wei Zhu, M.Sc., University of Minnesota, Twin Cities Campus