Segmented spin-echo BOLD fMRI using a variable flip angle FLEET acquisition with recursive RF pulse design for high spatial resolution fMRI

Program No:

3881 

Poster Type:

Digital Poster 

Authors:

Avery Berman, William Grissom, Thomas Witzel, Daniel Park, Olivia Viessmann, Kawin Setsompop, Jonathan Polimeni

Institutions:

Massachusetts General Hospital, Harvard Medical School, Vanderbilt University Institute of Imaging Science, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Harvard Medical School, Massachusetts Institute of Technology, Massachusetts General Hospital, Harvard Medical School, Massachusetts Institute of Technology

Digital Poster Presenter:

Avery Berman  
Massachusetts General Hospital

Synopsis:

Spin-echo (SE) EPI has long been desired for fMRI acquisitions
with reduced macrovascular sensitivity; however, to achieve a purely T2-weighted
signal, requires sampling a short window around the spin-echo—generally achieved
by a segmented readout. Segmented EPI is well-known to be temporally unstable due
to sensitivity to subject motion between segments. Here we propose a reordering
of the EPI segments, known as FLEET, combined with a variable flip angle
excitation to maximize the image signal level and a recursive RF pulse design
to maintain consistent slice profiles at the spin-echo. We demonstrate the
feasibility of this approach at 3T.

1100 fMRI:

fMRI Acquisition 2

Additional Category:

fMRI: Acquisition & Applications