L9: Understanding Exposure in Talc-Attributed Disease

Nadia Moore, PhD, DABT, ERT Moderator
Veritox, Inc.
Redmond , WA 
United States of America
 
Nadia Moore, PhD, DABT, ERT Presenter
Veritox, Inc.
Redmond , WA 
United States of America
 
Bryan Hardin, PhD, Fellow ATS Co-Presenter
Veritox, Inc.
Hilton Head Island , SC 
United States of America
 
Karin Hayman Co-Presenter
Veritox, Inc.
Redmond , WA 
United States of America
 
Wed, 5/23: 2:15 PM  - 3:15 PM 
Education Session 
Pennsylvania Convention Center 
Room: Room 109A, Room 109B 

Description

Recent litigation alleges talc exposure can cause both asbestos-related diseases (e.g., mesothelioma) and ovarian cancer. Occupational exposures occur during mining and processing operations; consumer exposures occur during use of products containing industrial-grade or cosmetic-grade talc. Talc's geological attributes, structural characteristics, and anticipated impurities will be discussed. We will clarify exposure profiles to talc associated respirable particles by explaining the fiber/cleavage fragment controversy and relate those exposure profiles to alleged asbestos-related diseases. We will review human and animal studies to demonstrate to date, exposure assessments and scientific studies do not support a causal role between talc and ovarian cancer.

Learning Outcomes

Upon completion of this presentation, attendees should be able to:

• Identify the chemical and physical characteristics of mined talc.
• Recognize why fibers and cleavage fragments are important in exposure assessments.
• Describe the physical particle characteristics of inhalable talc.
 

Learning Level(s)

Competent
Experienced

Topics

Exposure Assessment Strategies
Risk Assessment and Management
Toxicology